Translating Evidence into Practice
September 22-25, 2011 • Ottawa, Ontario, Canada

Agenda

September 22, 2011

Professional Workshops for Physicians and Healthcare Professionals
Morning Session: 9:00 am- 12:00 pm
 
Workshop 1 
How to Apply for Grants

The National Institutes of Health (NIH), part of the United States Department of Health & Human Services, is the primary U.S. Federal agency for conducting and supporting medical research. To realize its mission of extending healthy life and reducing the burdens of illness and disability, NIH funds grants that support the advancement of fundamental knowledge about the nature and behavior of living systems. As you plan, write and then submit an NIH application for a grant, it is important to know some important submission basics, such as what type of application will be needed (paper or electronic) and which forms are necessary, as well as links to contacts, important deadlines, a general timeline, and guidelines for tracking your application through the process. This Workshop will provide a useful overview of the NIH granting application process. Attendees will receive information on both the grant writing as well as how grants are reviewed to determine scientific and programmatic merit. Award fiscal monitoring, reporting and compliance issues will be discussed. Investigators are encouraged to review the NIH website for the fundamentals of grant writing prior to attending the workshop (http://grants.nih.gov/grants/grants_process.htm). 
 
Dennis F. Mangan, Ph.D.
Chair, Trans-NIH ME/CFS Research Working Group, Office of Research on Women’s Health, U.S. National Institutes of Health
Cheryl L. McDonald, M.D.
Medical Officer, National Heart, Lung and Blood Institute, U.S. National Institutes of Health

 
Workshop 2 
Treating Sleep, Pain and Fatigue in ME/ CFS Patients

Two experienced clinicians will discuss current issues in the management of PWCs (Persons with CFS or FM). Using a combination of brief lectures and actual cases, Drs. Bateman and Lapp hope to stimulate engaging discussions about the practical management of sleep, pain, fatigue, orthostatic problems, maladaptive behaviors, and 'whatever.' Attendees are encouraged to bring their questions to the workshop."
* This workshop will be repeated in the afternoon session
 
Charles W. Lapp, M.D.
Associate Clinical Professor, Duke University Medical Center, Charlotte, NC
Medical Director, Hunter-Hopkins Center, Charlotte, NC
Lucinda Bateman, M.D.
Adjunct Clinical Faculty, Departments of Anesthesiology, Family & Preventive Medicine, and Internal Medicine, University of Utah, Salt Lake City, UT
Director, Fatigue Consultation Clinic, Salt Lake City, UT
 
Workshop 3 
Pediatrics and CFS/ME

Workshop will provide an Introduction and brief description of CFS/ME in Paediatrics and will cover an overview of paediatric case definitions and other diagnostic issues: outline of illness severity, principal symptoms, relationship to puberty and immunisations, the importance of setting up a paediatric consultation and getting the parents involved. Attendees will walk through the patient evaluation process focusing on making the diagnosis taking into consideration such factors as history, psychological evaluation, physical examination, laboratory testing and other investigations. Discussion on diagnosis leads to the development of a Management / Treatment Plan with considerations for Lifestyle (including exercise, stress and dietary approaches), Addressing specific symptoms (sleep, pain, orthostatic intolerance etc.), Medication options, Counselling (child and family). Children diagnosed with CFS/ME will have special Educational needs such as Home-schooling, part-time attendance, material for teachers, travel and coping with exams and special social needs such as Social needs, interaction with peers, sports, other activities and the use of Parent and peer support groups to help cope. Discussion will conclude with a discussion on psychological effects on paediatric patients and their families, masked depression, suicide risk, isolation and family dynamics and conclude with a discussion of related conditions such as fibromyalgia, migraine, polycystic ovaries, and irritable bowel
 
Rosamund Vallings, MNZM, MB BS
Board Member, IACFS/ME
Family Physician, Howick Health and Medical Clinic, Auckland, New Zealand
 
Teruhisa Miike, M.D, Ph.D.
Board Member, IACFSME
Chief, Hyogo Children’s Sleep and Development Medical Research Center, Hyogo, Japan
 
Workshop 4 
Fibromyalgia Theory and Practice

The workshop will begin with an overview of the latest research findings in fibromyalgia and related chronic pain states, A particular focus will be on research suggesting that there are different underlying mechanisms of pain that will respond to different types of treatment. Attendees will be taught how to perform a clinical assessment that determines the underlying mechanism(s) of pain that an individual is experiencing, and then base treatment on those underlying mechanisms. The advantages of using combined pharmacological and non-pharmacological approaches will be emphasized. This approach moves towards “personalized analgesia” for the chronic pain
 
Daniel J. Clauw, M.D.
Professor of Anesthesiology, University of Michigan, Ann Arbor, MI
 
12:00 pm - 1:30 pm
Lunch Break/Visit Exhibits 

Note: Lunch is Self Pay from hotel and local restaurants
 
Afternoon Session: 1:30 pm – 4:30 pm

 
Workshop 5
Behavioral Assessment and Treatment of ME/CFS

In this introductory workshop on CFS and FM, participants will learn about practical methods of behavioral assessment and individualized treatment strategies. Our approach consists of self-management focused interventions and non-pharmacologic strategies for clinicians that can offer realistic hope for improvement in these patients. This workshop will benefit clinicians who work with CFS and FM patients.
 
Fred Friedberg, Ph.D.
President, IACFS/ME
Research Associate Professor, Stonybrook University, Stonybrook, NY
 
Leonard Jason, Ph.D.
Professor, DePaul University, Chicago, IL
 
Workshop 6 
Exercise Intolerance: Guide to Management and Treatment

This workshop will provide an overview of exercise intolerance and the management of post-exertional symptoms in CFS/ME. A review of assessment tools for measuring physiological responses during exercise will be included, and case studies examining both successes and common failures of persons with CFS/ME will be presented. Given the problem of exercise intolerance in CFS/ME, the workshop will conclude with a practical model that a clinician can use to safely and successfully implement activity management strategies. 
 
Staci R. Stevens, M.A.
Vice President, IACFS/ME
Founding Executive Director, Fatigue Lab, University of the Pacific, Stockton, CA
 
Christopher R. Snell, Ph.D.
Professor, Department of Sport Sciences, University of the Pacific, Stockton, CA
 
J. Mark VanNess, Ph.D.
Associate Professor, Department of Sport Sciences, University of the Pacific, Stockton, CA
Adjunct Professor, Department of Bioengineering, University of the Pacific
Adjunct Instructor, Department of Biology, University of the Pacific
 
Brian D. Moore, Ph.D., ATC
Assistant Professor, Sport Sciences Dept, University of the Pacific, Stockton, CA
 
Workshop 7 
Fibromyalgia Assessment and Treatment

Chronic widespread pain (CWP) is associated with many somatic symptoms, including fatigue, anxiety, depressed mood, and insomnia. Patients at the extreme end of the CWP spectrum have been labeled with fibromyalgia (FM). These patients show signs of abnormal pain processing including increased central pain sensitivity and dysfunctional endogenous pain modulation. During this workshop mechanism based assessments and therapies of FM will be discussed
 
Roland Staud, M.D.
Professor, University of Florida, Gainsville, FL
 
Workshop 8 
Treating Sleep, Pain and Fatigue in ME/ CFS Patients

Two experienced clinicians will discuss current issues in the management of PWCs (Persons with CFS or FM). Using a combination of brief lectures and actual cases, Drs. Bateman and Lapp hope to stimulate engaging discussions about the practical management of sleep, pain, fatigue, orthostatic problems, maladaptive behaviors, and 'whatever.' Attendees are encouraged to bring their questions to the workshop.
 
Charles W. Lapp, M.D.
Associate Clinical Professor, Duke University Medical Center, Charlotte, NC
Medical Director, Hunter-Hopkins Center, Charlotte, NC
 
Lucinda Bateman, M.D.
Adjunct Clinical Faculty, Departments of Anesthesiology, Family & Preventive Medicine, and Internal
Medicine, University of Utah, Salt Lake City, UT
Director, Fatigue Consultation Clinic, Salt Lake City, UT

September 22-25, 2011

General Session Agenda-Friday, September 23rd
 
8:30 am - 8:45 am 
Welcome and Introduction

Fred Friedberg, Ph.D.

President, IACFS/ME
 
8:45 am - 9:15 am 
Plenary Session: Gammaretroviruses of Mice and Their Links to Prostate Cancer and CFS/ME

Christine Kozak, Ph.D.

 
Paper Sessions following all the papers, the panel members will field questions written on cards by the audience and given to the chair as time permits.
 
9:15 am – 10:30 am 
Session: Virology Research 

Session Chair: Jose Montoya, M.D.

 
Blood XMRV Scientific Research Working Group: Latest Findings
Graham Simmons, Ph.D.
 
Detection Of Anti-XMRV Antibodies In Serum of CFS Patients and Healthy Blood Donors in Belgium
Kenny De Meirleir, M.D.
 
Detection of MLV-like Gag Sequences in Blood and Cell Lines Incubated With Plasma From CFS Patients and Controls
Maureen Hanson, Ph.D.
 
Chronic Fatigue, Nonrestorative sleep, Musculoskeletal Pain, and Depression in a Disabled Cohort of Survivors of Acute SARS Viral Disease
Harvey Moldofsky, M.D., Dip.Psych., FRCPC, FAPA
 
10:30 am – 10:45 am
Break / Visit Exhibits

 
10:45 am - 11:45 am
Session: Virology Research and Review 

Session Chair: Jose Montoya, M.D.

 
Role of the Immune Response in CFS
Jose Montoya, M.D.
 
The Case FOR Human Gamma Retroviruses (HGRV) in CFS/ME
Judy Mikovits, Ph.D.
 
The Case AGAINST Human Gamma Retroviruses (HGRV) in CFS/ME
John Coffin, Ph.D. 
 
11:45 am – 12:30 pm 
Session: Treatment Advances

Chair: Eleanor Stein, M.D.

Health/Performance and Response Status of XMRV/pMRV
Antibody Positive vs. Negative Chronic Fatigue
Syndrome (CFS) Subjects in a Phase III Clinical Trial
David R. Strayer, M.D.
 
Rifampin Augments the Effects of
Oxymatrine/Equilibrant (oxm/equi) In Patients with
Myalgic Encephalomyelitis/CFS
John K. Chia, M.D.
 
Brief Self- Management of UCF/CFS in Primary Care: A
Randomized Trial
Fred Friedberg, Ph.D.
 
12:30 pm - 2:00 pm 
Lunch Break/Visit Exhibitors

Note: Lunch is Self Pay from hotel and local restaurants
 
2:00 pm – 3:00 pm 
Session: Fibromyalgia: Are Tender Points Necessary? A Debate

Chair: Lucinda Bateman, M.D.

 
Tender Points are Important
Roland Staud, M.D.
 
Tender Points are Unnecessary
Daniel J. Clauw, M.D.
 
3:00 pm – 3:30 pm 
Break / Visit Exhibits

 
3:30 pm - 5:30 pm 
Session: Diagnosing CFS/ME; Difficult Clinical Cases

Session Chair: Nancy Klimas, M.D.

Case Presentations by: Charles Lapp, M.D., Lucinda
Bateman, MD, Rosamund Vallings, MNZM, MB BS, Derek
Enlander, M.D.
 
5:30 pm - 6:15 pm 
Visit Poster Presentations / Exhibits

 
6:15 pm - 7:15 pm 
Standardizing Data Collection in CFS/ME CASA Project

(collection, aggregation, storage and analyses)
Non CME Session
Session Co-Chairs: Elizabeth Unger, M.D., Ph.D. &
Dennis Mangan, Ph.D.

Fred Friedberg, Ph.D., Leonard Jason, Ph.D., Nancy
Klimas, M.D., Anthony Komaroff, M.D.

SATURDAY AGENDA

8:00 am – 9:30 am 
Session: Case Definitions for Research and Practice

Chair: Kenneth J. Friedman, PhD

 
The New International Consensus Criteria for ME: Content
and Context
Bruce M. Carruthers, M.D.
 
Contrasting Case Definitions
Leonard Jason, Ph.D.
 
Data Mining
Leonard Jason, Ph.D.
 
Pathways to Pathogenesis: Standardized Measures of CFS/ME Illness Domains
Elizabeth R.Unger, M.D., Ph.D. 
 
9:30 am – 10:30 am 
Session: Identifying Abnormalities in CFS/ME: The Importance of Exercise Challenge

Chair Staci R. Stevens, M.A.

 
Exercise Testing to Quantify Effects of Fatigue on
Functional Capacity in Patients With CFS
Betsy A. Keller, Ph.D.
 
The Importance of Exercise Challenge
Christopher Snell, Ph.D.
 
10:30 am - 11:00 am Break/Visit Exhibits

 
11:00 am – 12:15 pm 
Session 9: The Latest Research in Immunology

Chair: Nancy Klimas, M.D.

 
Natural Killer Cell Number and Function in a Prospective
Cohort of Adolescents with Chronic Fatigue Syndrome
and Controls Following Mononucleosis
Benjamin Katz, M.D.
 
Disparities In Innate and Adaptive Immune Cell Activities
in Chronic Fatigue Syndrome
Ekua W. Brenu, PhD candidate
 
Longitudinal Assessment of Adaptive Immune Regulation
in Chronic Fatigue Syndrome
Ekua W. Brenu, PhD candidate
 
Promoter DNA Methylation and Expression of Perforin in
CFS and Controls
Virginia R. Falkenberg, Ph.D.
 
12:15 pm – 1:30 pm
Lunch Break/Visit Exhibits

Note: Lunch is Self Pay from hotel and local restaurants.
 
12:30 pm – 1:15 pm
Breakout Session: Mainstreaming ME/CFS Researchers
and Healthcare Providers into Our Peer Communities

Chair: Kenneth J. Friedman, Ph.D . Non CME Session
 
 
1:30 pm – 2:30 pm 
Session: New Developments in Pediatric ME/CFS

Chair: Teruhisa Miike, M.D, Ph.D.
 
Linking Lymphocyte Metabolites with Clinical Course in Post-Infectious Fatigue
Gordon Broderick, Ph.D.
 
A Trial for Prevention of CCFS Onset from The View Point of Sleep Issue
Terusha Miike, M.D., Ph.D.
 
Therapeutic Outcome by Two-months Intensive Sleep-
Wake Circadian Rhythm Treatments in
Japanese Children and Adolescents with Chronic Fatigue
Seiki Tajima, M.D.
 
What is the Natural History of Chronic Fatigue Syndrome in Young People?
Katherine S. Rowe, MBBS, M.D., FRACP
 
2:30 pm - 3:00 pm 
Break / Visit Exhibits

 
3:00 pm – 4:00 pm 
Session: New Developments in Epidemiology

Chair: Kenneth J. Friedman, Ph.D .

 
Natural History
Leonard Jason, Ph.D.
 
CFS Knowledge And Illness Management Behavior Among
U.S. Healthcare Providers and The Public
Elizabeth Unger, M.D., Ph.D.
 
Profile of the Patient with Chronic Fatigue Syndrome; Experience with a Population-Based Registry
Jose Alegre, M.D.
 
4:00 pm - 5:00 pm 
Visit Poster Presentations / Exhibits

 
5:00 pm - 6:00 pm 
IACFS/ME Membership Business Meeting

 
6:00 pm – 7:00 pm 
IACFS/ME Social/Cocktails Hour

 
7:00 pm - 8:00 pm 
IACFS/ME Banquet Dinner

 
8:00 pm – 9:00 pm 
Awards Presentation & Banquet Keynote
Ten Important Facts Derived from M.E./CFS History and That Can Improve M.E./CFS Research

Byron M. Hyde M.D.

SUNDAY AGENDA

8:30 am - 10:00 am
Session 12: Research Developments in Genomics and Genetics

Chair: Christine Kozak, Ph.D.

 
Expression Patterns of miRNAs in Lymphocytes In Patients
with Chronic Fatigue Syndrome
Ekua W. Brenu, PhD candidate
 
Pathway-Focused Genetic Evaluation of Immune and
Inflammation Related Genes in CFS
Mangalathu S. Rajeevan, Ph.D.
 
Gene Expression Of Sensory Ion Channels, Adrenegic
Receptors and Cytokines: Potential Biomarkers for CFS
and Fibromyalgia
Lucinda Bateman, M.D.
 
Gene-Exposure Interactions In The Etiology Of Gulf War
Illness: Evidence Of Increased Vulnerability to
Neurotoxicants in Identifiable Veteran Subgroups
Lea Steele, Ph.D.
 
Comparing Gene Expression Patterns in CFS and GWI Using the Kerr ME/CFS Platform
Lina Garcia, M.D.
 
10:00 am – 10:15 am 
Break

 
10:15 am – 11:45 am 
Session: Advances in Brain and Neuroendocrine Functioning
Chair: Andrew H. Miller, M.D.

 
Regional Grey and White Matter Volumetric Changes in
Chronic Fatigue Syndrome (Myalgic Encephalomyelitis):A
Voxel-Based Morphometry 3T MRI Study
I. H. Treasaden, M.B., B.S., LRCP, MRCS, FRCPsych, LLM
 
Evidence For Reduced Aldosterone in Persons with Chronic Fatigue Syndrome
Roumiana S. Boneva, M.D., Ph.D.
 
Interaction of Self-And Illness-Related Cognitive Processing In The Right Anterior Insula of CFS Patients: An fMRI Study
Andrew H. Miller, M.D.
 
Decreased Basal Ganglia Activation in CFS Subjects is
Associated With Increased Fatigue
Andrew H. Miller, M.D.
 
Assessment of Regional Cerebral Blood Flow in CFS Using Arterial Spin Labeling MRI
Jonathan P. Dyke, Ph.D.
 
11:45 am – 1:00 pm 
Lunch / Visit Exhibits
Networking Lunch - Offering an opportunity for clinicians to network and talk about assessment and treatment issues.

 
1:00 pm – 2:00 pm 
Session: IACFS/ME Clinical Practice Manual: Developing A New Primer
Guidelines Panel

Fred Friedberg, Ph.D., Rosemary Underhill, M.D., Rosamund Vallings, MNZM, MB BS, Alan Gurwitt, M.D.
Leonard A. Jason, Ph.D., Lucinda Bateman, M.D., Kenneth Friedman, Ph.D.
 
2:00 pm – 2:30 pm 
Summary of the Conference
Anthony L. Komaroff, M.D.

 
2:30 pm 
Conference Concludes

 

 


Translating Evidence into Practice
September 22-25, 2011 • Ottawa, Ontario, Canada

Agenda

September 22, 2011

Professional Workshops for Physicians and Healthcare Professionals
Morning Session: 9:00 am- 12:00 pm
 
Workshop 1 
How to Apply for Grants

The National Institutes of Health (NIH), part of the United States Department of Health & Human Services, is the primary U.S. Federal agency for conducting and supporting medical research. To realize its mission of extending healthy life and reducing the burdens of illness and disability, NIH funds grants that support the advancement of fundamental knowledge about the nature and behavior of living systems. As you plan, write and then submit an NIH application for a grant, it is important to know some important submission basics, such as what type of application will be needed (paper or electronic) and which forms are necessary, as well as links to contacts, important deadlines, a general timeline, and guidelines for tracking your application through the process. This Workshop will provide a useful overview of the NIH granting application process. Attendees will receive information on both the grant writing as well as how grants are reviewed to determine scientific and programmatic merit. Award fiscal monitoring, reporting and compliance issues will be discussed. Investigators are encouraged to review the NIH website for the fundamentals of grant writing prior to attending the workshop (http://grants.nih.gov/grants/grants_process.htm). 
 
Dennis F. Mangan, Ph.D.
Chair, Trans-NIH ME/CFS Research Working Group, Office of Research on Women’s Health, U.S. National Institutes of Health
Cheryl L. McDonald, M.D.
Medical Officer, National Heart, Lung and Blood Institute, U.S. National Institutes of Health

 
Workshop 2 
Treating Sleep, Pain and Fatigue in ME/ CFS Patients

Two experienced clinicians will discuss current issues in the management of PWCs (Persons with CFS or FM). Using a combination of brief lectures and actual cases, Drs. Bateman and Lapp hope to stimulate engaging discussions about the practical management of sleep, pain, fatigue, orthostatic problems, maladaptive behaviors, and 'whatever.' Attendees are encouraged to bring their questions to the workshop."
* This workshop will be repeated in the afternoon session
 
Charles W. Lapp, M.D.
Associate Clinical Professor, Duke University Medical Center, Charlotte, NC
Medical Director, Hunter-Hopkins Center, Charlotte, NC
Lucinda Bateman, M.D.
Adjunct Clinical Faculty, Departments of Anesthesiology, Family & Preventive Medicine, and Internal Medicine, University of Utah, Salt Lake City, UT
Director, Fatigue Consultation Clinic, Salt Lake City, UT
 
Workshop 3 
Pediatrics and CFS/ME

Workshop will provide an Introduction and brief description of CFS/ME in Paediatrics and will cover an overview of paediatric case definitions and other diagnostic issues: outline of illness severity, principal symptoms, relationship to puberty and immunisations, the importance of setting up a paediatric consultation and getting the parents involved. Attendees will walk through the patient evaluation process focusing on making the diagnosis taking into consideration such factors as history, psychological evaluation, physical examination, laboratory testing and other investigations. Discussion on diagnosis leads to the development of a Management / Treatment Plan with considerations for Lifestyle (including exercise, stress and dietary approaches), Addressing specific symptoms (sleep, pain, orthostatic intolerance etc.), Medication options, Counselling (child and family). Children diagnosed with CFS/ME will have special Educational needs such as Home-schooling, part-time attendance, material for teachers, travel and coping with exams and special social needs such as Social needs, interaction with peers, sports, other activities and the use of Parent and peer support groups to help cope. Discussion will conclude with a discussion on psychological effects on paediatric patients and their families, masked depression, suicide risk, isolation and family dynamics and conclude with a discussion of related conditions such as fibromyalgia, migraine, polycystic ovaries, and irritable bowel
 
Rosamund Vallings, MNZM, MB BS
Board Member, IACFS/ME
Family Physician, Howick Health and Medical Clinic, Auckland, New Zealand
 
Teruhisa Miike, M.D, Ph.D.
Board Member, IACFSME
Chief, Hyogo Children’s Sleep and Development Medical Research Center, Hyogo, Japan
 
Workshop 4 
Fibromyalgia Theory and Practice

The workshop will begin with an overview of the latest research findings in fibromyalgia and related chronic pain states, A particular focus will be on research suggesting that there are different underlying mechanisms of pain that will respond to different types of treatment. Attendees will be taught how to perform a clinical assessment that determines the underlying mechanism(s) of pain that an individual is experiencing, and then base treatment on those underlying mechanisms. The advantages of using combined pharmacological and non-pharmacological approaches will be emphasized. This approach moves towards “personalized analgesia” for the chronic pain
 
Daniel J. Clauw, M.D.
Professor of Anesthesiology, University of Michigan, Ann Arbor, MI
 
12:00 pm - 1:30 pm
Lunch Break/Visit Exhibits 

Note: Lunch is Self Pay from hotel and local restaurants
 
Afternoon Session: 1:30 pm – 4:30 pm

 
Workshop 5
Behavioral Assessment and Treatment of ME/CFS

In this introductory workshop on CFS and FM, participants will learn about practical methods of behavioral assessment and individualized treatment strategies. Our approach consists of self-management focused interventions and non-pharmacologic strategies for clinicians that can offer realistic hope for improvement in these patients. This workshop will benefit clinicians who work with CFS and FM patients.
 
Fred Friedberg, Ph.D.
President, IACFS/ME
Research Associate Professor, Stonybrook University, Stonybrook, NY
 
Leonard Jason, Ph.D.
Professor, DePaul University, Chicago, IL
 
Workshop 6 
Exercise Intolerance: Guide to Management and Treatment

This workshop will provide an overview of exercise intolerance and the management of post-exertional symptoms in CFS/ME. A review of assessment tools for measuring physiological responses during exercise will be included, and case studies examining both successes and common failures of persons with CFS/ME will be presented. Given the problem of exercise intolerance in CFS/ME, the workshop will conclude with a practical model that a clinician can use to safely and successfully implement activity management strategies. 
 
Staci R. Stevens, M.A.
Vice President, IACFS/ME
Founding Executive Director, Fatigue Lab, University of the Pacific, Stockton, CA
 
Christopher R. Snell, Ph.D.
Professor, Department of Sport Sciences, University of the Pacific, Stockton, CA
 
J. Mark VanNess, Ph.D.
Associate Professor, Department of Sport Sciences, University of the Pacific, Stockton, CA
Adjunct Professor, Department of Bioengineering, University of the Pacific
Adjunct Instructor, Department of Biology, University of the Pacific
 
Brian D. Moore, Ph.D., ATC
Assistant Professor, Sport Sciences Dept, University of the Pacific, Stockton, CA
 
Workshop 7 
Fibromyalgia Assessment and Treatment

Chronic widespread pain (CWP) is associated with many somatic symptoms, including fatigue, anxiety, depressed mood, and insomnia. Patients at the extreme end of the CWP spectrum have been labeled with fibromyalgia (FM). These patients show signs of abnormal pain processing including increased central pain sensitivity and dysfunctional endogenous pain modulation. During this workshop mechanism based assessments and therapies of FM will be discussed
 
Roland Staud, M.D.
Professor, University of Florida, Gainsville, FL
 
Workshop 8 
Treating Sleep, Pain and Fatigue in ME/ CFS Patients

Two experienced clinicians will discuss current issues in the management of PWCs (Persons with CFS or FM). Using a combination of brief lectures and actual cases, Drs. Bateman and Lapp hope to stimulate engaging discussions about the practical management of sleep, pain, fatigue, orthostatic problems, maladaptive behaviors, and 'whatever.' Attendees are encouraged to bring their questions to the workshop.
 
Charles W. Lapp, M.D.
Associate Clinical Professor, Duke University Medical Center, Charlotte, NC
Medical Director, Hunter-Hopkins Center, Charlotte, NC
 
Lucinda Bateman, M.D.
Adjunct Clinical Faculty, Departments of Anesthesiology, Family & Preventive Medicine, and Internal
Medicine, University of Utah, Salt Lake City, UT
Director, Fatigue Consultation Clinic, Salt Lake City, UT

September 22-25, 2011

General Session Agenda-Friday, September 23rd
 
8:30 am - 8:45 am 
Welcome and Introduction

Fred Friedberg, Ph.D.

President, IACFS/ME
 
8:45 am - 9:15 am 
Plenary Session: Gammaretroviruses of Mice and Their Links to Prostate Cancer and CFS/ME

Christine Kozak, Ph.D.

 
Paper Sessions following all the papers, the panel members will field questions written on cards by the audience and given to the chair as time permits.
 
9:15 am – 10:30 am 
Session: Virology Research 

Session Chair: Jose Montoya, M.D.

 
Blood XMRV Scientific Research Working Group: Latest Findings
Graham Simmons, Ph.D.
 
Detection Of Anti-XMRV Antibodies In Serum of CFS Patients and Healthy Blood Donors in Belgium
Kenny De Meirleir, M.D.
 
Detection of MLV-like Gag Sequences in Blood and Cell Lines Incubated With Plasma From CFS Patients and Controls
Maureen Hanson, Ph.D.
 
Chronic Fatigue, Nonrestorative sleep, Musculoskeletal Pain, and Depression in a Disabled Cohort of Survivors of Acute SARS Viral Disease
Harvey Moldofsky, M.D., Dip.Psych., FRCPC, FAPA
 
10:30 am – 10:45 am
Break / Visit Exhibits

 
10:45 am - 11:45 am
Session: Virology Research and Review 

Session Chair: Jose Montoya, M.D.

 
Role of the Immune Response in CFS
Jose Montoya, M.D.
 
The Case FOR Human Gamma Retroviruses (HGRV) in CFS/ME
Judy Mikovits, Ph.D.
 
The Case AGAINST Human Gamma Retroviruses (HGRV) in CFS/ME
John Coffin, Ph.D. 
 
11:45 am – 12:30 pm 
Session: Treatment Advances

Chair: Eleanor Stein, M.D.

Health/Performance and Response Status of XMRV/pMRV
Antibody Positive vs. Negative Chronic Fatigue
Syndrome (CFS) Subjects in a Phase III Clinical Trial
David R. Strayer, M.D.
 
Rifampin Augments the Effects of
Oxymatrine/Equilibrant (oxm/equi) In Patients with
Myalgic Encephalomyelitis/CFS
John K. Chia, M.D.
 
Brief Self- Management of UCF/CFS in Primary Care: A
Randomized Trial
Fred Friedberg, Ph.D.
 
12:30 pm - 2:00 pm 
Lunch Break/Visit Exhibitors

Note: Lunch is Self Pay from hotel and local restaurants
 
2:00 pm – 3:00 pm 
Session: Fibromyalgia: Are Tender Points Necessary? A Debate

Chair: Lucinda Bateman, M.D.

 
Tender Points are Important
Roland Staud, M.D.
 
Tender Points are Unnecessary
Daniel J. Clauw, M.D.
 
3:00 pm – 3:30 pm 
Break / Visit Exhibits

 
3:30 pm - 5:30 pm 
Session: Diagnosing CFS/ME; Difficult Clinical Cases

Session Chair: Nancy Klimas, M.D.

Case Presentations by: Charles Lapp, M.D., Lucinda
Bateman, MD, Rosamund Vallings, MNZM, MB BS, Derek
Enlander, M.D.
 
5:30 pm - 6:15 pm 
Visit Poster Presentations / Exhibits

 
6:15 pm - 7:15 pm 
Standardizing Data Collection in CFS/ME CASA Project

(collection, aggregation, storage and analyses)
Non CME Session
Session Co-Chairs: Elizabeth Unger, M.D., Ph.D. &
Dennis Mangan, Ph.D.

Fred Friedberg, Ph.D., Leonard Jason, Ph.D., Nancy
Klimas, M.D., Anthony Komaroff, M.D.

SATURDAY AGENDA

8:00 am – 9:30 am 
Session: Case Definitions for Research and Practice

Chair: Kenneth J. Friedman, PhD

 
The New International Consensus Criteria for ME: Content
and Context
Bruce M. Carruthers, M.D.
 
Contrasting Case Definitions
Leonard Jason, Ph.D.
 
Data Mining
Leonard Jason, Ph.D.
 
Pathways to Pathogenesis: Standardized Measures of CFS/ME Illness Domains
Elizabeth R.Unger, M.D., Ph.D. 
 
9:30 am – 10:30 am 
Session: Identifying Abnormalities in CFS/ME: The Importance of Exercise Challenge

Chair Staci R. Stevens, M.A.

 
Exercise Testing to Quantify Effects of Fatigue on
Functional Capacity in Patients With CFS
Betsy A. Keller, Ph.D.
 
The Importance of Exercise Challenge
Christopher Snell, Ph.D.
 
10:30 am - 11:00 am Break/Visit Exhibits

 
11:00 am – 12:15 pm 
Session 9: The Latest Research in Immunology

Chair: Nancy Klimas, M.D.

 
Natural Killer Cell Number and Function in a Prospective
Cohort of Adolescents with Chronic Fatigue Syndrome
and Controls Following Mononucleosis
Benjamin Katz, M.D.
 
Disparities In Innate and Adaptive Immune Cell Activities
in Chronic Fatigue Syndrome
Ekua W. Brenu, PhD candidate
 
Longitudinal Assessment of Adaptive Immune Regulation
in Chronic Fatigue Syndrome
Ekua W. Brenu, PhD candidate
 
Promoter DNA Methylation and Expression of Perforin in
CFS and Controls
Virginia R. Falkenberg, Ph.D.
 
12:15 pm – 1:30 pm
Lunch Break/Visit Exhibits

Note: Lunch is Self Pay from hotel and local restaurants.
 
12:30 pm – 1:15 pm
Breakout Session: Mainstreaming ME/CFS Researchers
and Healthcare Providers into Our Peer Communities

Chair: Kenneth J. Friedman, Ph.D . Non CME Session
 
 
1:30 pm – 2:30 pm 
Session: New Developments in Pediatric ME/CFS

Chair: Teruhisa Miike, M.D, Ph.D.
 
Linking Lymphocyte Metabolites with Clinical Course in Post-Infectious Fatigue
Gordon Broderick, Ph.D.
 
A Trial for Prevention of CCFS Onset from The View Point of Sleep Issue
Terusha Miike, M.D., Ph.D.
 
Therapeutic Outcome by Two-months Intensive Sleep-
Wake Circadian Rhythm Treatments in
Japanese Children and Adolescents with Chronic Fatigue
Seiki Tajima, M.D.
 
What is the Natural History of Chronic Fatigue Syndrome in Young People?
Katherine S. Rowe, MBBS, M.D., FRACP
 
2:30 pm - 3:00 pm 
Break / Visit Exhibits

 
3:00 pm – 4:00 pm 
Session: New Developments in Epidemiology

Chair: Kenneth J. Friedman, Ph.D .

 
Natural History
Leonard Jason, Ph.D.
 
CFS Knowledge And Illness Management Behavior Among
U.S. Healthcare Providers and The Public
Elizabeth Unger, M.D., Ph.D.
 
Profile of the Patient with Chronic Fatigue Syndrome; Experience with a Population-Based Registry
Jose Alegre, M.D.
 
4:00 pm - 5:00 pm 
Visit Poster Presentations / Exhibits

 
5:00 pm - 6:00 pm 
IACFS/ME Membership Business Meeting

 
6:00 pm – 7:00 pm 
IACFS/ME Social/Cocktails Hour

 
7:00 pm - 8:00 pm 
IACFS/ME Banquet Dinner

 
8:00 pm – 9:00 pm 
Awards Presentation & Banquet Keynote
Ten Important Facts Derived from M.E./CFS History and That Can Improve M.E./CFS Research

Byron M. Hyde M.D.

SUNDAY AGENDA

8:30 am - 10:00 am
Session 12: Research Developments in Genomics and Genetics

Chair: Christine Kozak, Ph.D.

 
Expression Patterns of miRNAs in Lymphocytes In Patients
with Chronic Fatigue Syndrome
Ekua W. Brenu, PhD candidate
 
Pathway-Focused Genetic Evaluation of Immune and
Inflammation Related Genes in CFS
Mangalathu S. Rajeevan, Ph.D.
 
Gene Expression Of Sensory Ion Channels, Adrenegic
Receptors and Cytokines: Potential Biomarkers for CFS
and Fibromyalgia
Lucinda Bateman, M.D.
 
Gene-Exposure Interactions In The Etiology Of Gulf War
Illness: Evidence Of Increased Vulnerability to
Neurotoxicants in Identifiable Veteran Subgroups
Lea Steele, Ph.D.
 
Comparing Gene Expression Patterns in CFS and GWI Using the Kerr ME/CFS Platform
Lina Garcia, M.D.
 
10:00 am – 10:15 am 
Break

 
10:15 am – 11:45 am 
Session: Advances in Brain and Neuroendocrine Functioning
Chair: Andrew H. Miller, M.D.

 
Regional Grey and White Matter Volumetric Changes in
Chronic Fatigue Syndrome (Myalgic Encephalomyelitis):A
Voxel-Based Morphometry 3T MRI Study
I. H. Treasaden, M.B., B.S., LRCP, MRCS, FRCPsych, LLM
 
Evidence For Reduced Aldosterone in Persons with Chronic Fatigue Syndrome
Roumiana S. Boneva, M.D., Ph.D.
 
Interaction of Self-And Illness-Related Cognitive Processing In The Right Anterior Insula of CFS Patients: An fMRI Study
Andrew H. Miller, M.D.
 
Decreased Basal Ganglia Activation in CFS Subjects is
Associated With Increased Fatigue
Andrew H. Miller, M.D.
 
Assessment of Regional Cerebral Blood Flow in CFS Using Arterial Spin Labeling MRI
Jonathan P. Dyke, Ph.D.
 
11:45 am – 1:00 pm 
Lunch / Visit Exhibits
Networking Lunch - Offering an opportunity for clinicians to network and talk about assessment and treatment issues.

 
1:00 pm – 2:00 pm 
Session: IACFS/ME Clinical Practice Manual: Developing A New Primer
Guidelines Panel

Fred Friedberg, Ph.D., Rosemary Underhill, M.D., Rosamund Vallings, MNZM, MB BS, Alan Gurwitt, M.D.
Leonard A. Jason, Ph.D., Lucinda Bateman, M.D., Kenneth Friedman, Ph.D.
 
2:00 pm – 2:30 pm 
Summary of the Conference
Anthony L. Komaroff, M.D.

 
2:30 pm 
Conference Concludes